Expression of G qα and PLC-β in Scar and Border Tissue in Heart Failure Due to Myocardial Infarction | Zendy

Haisong Ju | Zendy; Shufang Zhao | Zendy; Paramjit S. Tappia | Zendy; Vincenzo Panagia | Zendy; Ian Dixon | Zendy

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Expression of G _qα and PLC-β in Scar and Border Tissue in Heart Failure Due to Myocardial Infarction

Author(s) -

Haisong Ju,

Shufang Zhao,

Paramjit S. Tappia,

Vincenzo Panagia,

Ian Dixon

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.9.892

Subject(s) - heart failure , medicine , gq alpha subunit , myocardial infarction , ventricle , cardiology , downregulation and upregulation , endocrinology , myocyte , fibrosis , ventricular remodeling , endothelin receptor , angiotensin ii , receptor , g protein , biology , biochemistry , gene

Large transmural myocardial infarction (MI) leads to maladaptive cardiac remodeling and places patients at increased risk of congestive heart failure. Angiotensin II, endothelin, and alpha1-adrenergic receptor agonists are implicated in the development of cardiac hypertrophy, interstitial fibrosis, and heart failure after MI. Because these agonists are coupled to and activate Gq alpha protein in the heart, the aim of the present study was to investigate Gq alpha expression and function in cardiac remodeling and heart failure after MI.

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