Randomized, Double-Blind, Placebo-Controlled Study of Ascorbate on the Preventive Effect of Nitrate Tolerance in Patients With Congestive Heart Failure | Zendy

Hideki Watanabe | Zendy; Masaaki Kakihana | Zendy; Sadanori Ohtsuka | Zendy; Yasuro Sugishita | Zendy

Open Access

Randomized, Double-Blind, Placebo-Controlled Study of Ascorbate on the Preventive Effect of Nitrate Tolerance in Patients With Congestive Heart Failure

Author(s) -

Hideki Watanabe,

Masaaki Kakihana,

Sadanori Ohtsuka,

Yasuro Sugishita

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.9.886

Subject(s) - medicine , heart failure , placebo , pulmonary wedge pressure , hemodynamics , cardiology , pulmonary artery , vitamin , anesthesia , alternative medicine , pathology

Reduced cGMP production caused by increased superoxide has been proposed as a mechanism of nitrate tolerance during continuous nitrate therapy. This study was designed to evaluate the effects of ascorbate, an antioxidant, on the development of nitrate tolerance during continuous nitrate therapy in patients with congestive heart failure.

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