Relationships of Abdominal Obesity and Hyperinsulinemia to Angiographically Assessed Coronary Artery Disease in Men With Known Mutations in the LDL Receptor Gene | Zendy

Daniel Gaudet | Zendy; MarieClaude Vohl | Zendy; Patrice Perron | Zendy; G Tremblay | Zendy; Claude Gagné | Zendy; Daniel Lesiège | Zendy; Jean Bergeron | Zendy; Sital Moorjani | Zendy; Jean–Pierre Després | Zendy

Open Access

Relationships of Abdominal Obesity and Hyperinsulinemia to Angiographically Assessed Coronary Artery Disease in Men With Known Mutations in the LDL Receptor Gene

Author(s) -

Daniel Gaudet,

MarieClaude Vohl,

Patrice Perron,

G Tremblay,

Claude Gagné,

Daniel Lesiège,

Jean Bergeron,

Sital Moorjani,

Jean–Pierre Després

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.9.871

Subject(s) - medicine , hyperinsulinemia , abdominal obesity , endocrinology , coronary artery disease , waist , odds ratio , apolipoprotein b , obesity , cardiology , risk factor , insulin resistance , cholesterol

Patients with a mutation in the LDL receptor gene (familial hypercholesterolemia, or FH) are characterized by substantial elevations in plasma LDL cholesterol and are at higher risk of developing coronary artery disease (CAD). Correlates of abdominal obesity may also contribute to the risk of ischemic cardiac events. Whether the hyperinsulinemic-insulin-resistant state of abdominal obesity affects coronary atherosclerosis among FH patients has not been determined.

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