Disparate Effects of Deficient Expression of Connexin43 on Atrial and Ventricular Conduction | Zendy

Suma A. Thomas | Zendy; Richard B. Schuessler | Zendy; Charles I. Berul | Zendy; Michael A. Beardslee | Zendy; Eric C. Beyer | Zendy; Michael E. Mendelsohn | Zendy; Jeffrey E. Saffitz | Zendy

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Disparate Effects of Deficient Expression of Connexin43 on Atrial and Ventricular Conduction

Author(s) -

Suma A. Thomas,

Richard B. Schuessler,

Charles I. Berul,

Michael A. Beardslee,

Eric C. Beyer,

Michael E. Mendelsohn,

Jeffrey E. Saffitz

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.7.686

Subject(s) - connexin , gap junction , medicine , cardiology , nerve conduction velocity , ventricle , myocyte , electrophysiology , qrs complex , electrical conduction system of the heart , endocrinology , intracellular , electrocardiography , biology , microbiology and biotechnology

Myocardial conduction depends on intercellular transfer of current at gap junctions. Atrial myocytes express three different gap junction channel proteins-connexin43 (Cx43), connexin45 (Cx45), and connexin40 (Cx40)-- whereas ventricular myocytes express only Cx43 and Cx45. However, the physiological roles of individual connexins are unknown. We have previously shown that mice heterozygous for a null mutation in the gene encoding Cx43 (Cx43(+/-) mice) express 50% of the normal amount of Cx43 in ventricular myocardium and exhibit marked slowing of ventricular conduction.

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