Thrombin-Induced Mitogenesis in Coronary Artery Smooth Muscle Cells Is Potentiated by Thromboxane A 2 and Involves Upregulation of Thromboxane Receptor mRNA | Zendy

Tom-Philipp Zucker | Zendy; Detlef Bönisch | Zendy; Stephanie Muck | Zendy; A.-A. Weber | Zendy; Ellen Bretschneider | Zendy; Erika Glusa | Zendy; Karsten Schrör | Zendy

Open Access

Thrombin-Induced Mitogenesis in Coronary Artery Smooth Muscle Cells Is Potentiated by Thromboxane A ₂ and Involves Upregulation of Thromboxane Receptor mRNA

Author(s) -

Tom-Philipp Zucker,

Detlef Bönisch,

Stephanie Muck,

A.-A. Weber,

Ellen Bretschneider,

Erika Glusa,

Karsten Schrör

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.6.589

Subject(s) - thrombin , thromboxane receptor , thromboxane , downregulation and upregulation , thromboxane a2 , thrombin receptor , thromboxane a synthase , medicine , endocrinology , receptor , platelet , biology , biochemistry , gene

Previous studies have shown that thrombin is a potent though slow-acting mitogen for vascular smooth muscle cells (SMC). Because thrombin generation in vivo is accompanied by platelet activation, it has been suggested that platelet-derived factors might enhance thrombin-induced SMC proliferation. No information is available so far on the possible role of thromboxane A2.

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