Potentiated Angiogenic Effect of Scatter Factor/Hepatocyte Growth Factor via Induction of Vascular Endothelial Growth Factor | Zendy

Éric Van Belle | Zendy; Bernhard Witzenbichler | Zendy; Donghui Chen | Zendy; Marcy Silver | Zendy; Ling Chang | Zendy; Ralph Schwall | Zendy; Jeffrey M. Isner | Zendy

Open Access

Potentiated Angiogenic Effect of Scatter Factor/Hepatocyte Growth Factor via Induction of Vascular Endothelial Growth Factor

Author(s) -

Éric Van Belle,

Bernhard Witzenbichler,

Donghui Chen,

Marcy Silver,

Ling Chang,

Ralph Schwall,

Jeffrey M. Isner

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.4.381

Subject(s) - hepatocyte growth factor , angiogenesis , vascular endothelial growth factor , in vivo , growth factor , medicine , endocrinology , cell growth , in vitro , transforming growth factor , receptor , biology , biochemistry , microbiology and biotechnology , vegf receptors

Scatter factor/hepatocyte growth factor (SF/HGF) is a pleiotropic growth factor that stimulates proliferation and migration of endothelial cells (ECs) via the c-Met receptor, present on ECs as well as other cell types, including smooth muscle cells (SMCs). We studied the effects of recombinant human (rh) SF/HGF in vitro and in vivo in a rabbit model of hindlimb ischemia. We further compared these effects with those of recombinant human vascular endothelial growth factor (rhVEGF165), an EC-specific mitogen.

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