Open AccessAttenuation of Ischemia/Reperfusion Injury in Rats by a Caspase Inhibitor
Author(s) -
Hiroyuki Yaoita,
Kazuei Ogawa,
Kazuhira Maehara,
Yukio Maruyama
Publication year - 1998
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.97.3.276
Subject(s) - tunel assay , medicine , dna laddering , myocardial infarction , ischemia , reperfusion injury , apoptosis , cardiology , anesthesia , endocrinology , biochemistry , programmed cell death , chemistry , dna fragmentation , immunohistochemistry
Z-Val-Ala-Asp(OMe)-CH2F (ZVAD-fmk), a tripeptide inhibitor of the caspase interleukin-1beta-converting enzyme family of cysteine proteases, may reduce myocardial reperfusion injury in vivo by attenuating cardiomyocyte apoptosis within the ischemic area at risk.
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