Endothelin-1 Inhibits Endothelin-Converting Enzyme-1 Expression in Cultured Rat Pulmonary Endothelial Cells | Zendy

Shojiro Naomi | Zendy; Taisuke Iwaoka | Zendy; Tumba G. Disashi | Zendy; Junnosuke Inoue | Zendy; Yoshie Kanesaka | Zendy; Hiroshi Tokunaga | Zendy; Kimio Tomita | Zendy

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Endothelin-1 Inhibits Endothelin-Converting Enzyme-1 Expression in Cultured Rat Pulmonary Endothelial Cells

Author(s) -

Shojiro Naomi,

Taisuke Iwaoka,

Tumba G. Disashi,

Junnosuke Inoue,

Yoshie Kanesaka,

Hiroshi Tokunaga,

Kimio Tomita

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.3.234

Subject(s) - ionomycin , endothelin 1 , endothelin receptor , protein kinase c , messenger rna , endothelins , medicine , endocrinology , activator (genetics) , receptor , northern blot , receptor antagonist , microbiology and biotechnology , biology , antagonist , signal transduction , calcium , biochemistry , gene

The lung expresses large amounts of endothelin-converting enzyme-1 (ECE-1), which catalyzes a step in the biosynthesis of potent vasoactive endothelin-1 (ET-1) from the inactive intermediate big ET-1. Because there has been no report concerning a possible relationship between ET-1 and ECE-1, we investigated the effects of ET-1 on ECE-1 expression in cultured rat pulmonary endothelial cells.

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