Open AccessInduction of Plasminogen Activator Inhibitor Type 1 and Type 1 Collagen Expression in Rat Cardiac Microvascular Endothelial Cells by Interleukin-1 and Its Dependence on Oxygen-Centered Free Radicals
Author(s) -
Hitoshi Okada,
Janet WoodcockMitchell,
John J. Mitchell,
Tomohiro Sakamoto,
Kousuke Marutsuka,
Burton E. Sobel,
Satoshi Fujii
Publication year - 1998
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.97.21.2175
Subject(s) - plasminogen activator , medicine , plasminogen activator inhibitor 1 , radical , microbiology and biotechnology , endothelium , interleukin , interleukin 1β , type i collagen , endothelial stem cell , cytokine , biochemistry , biology , in vitro
Ischemia with or without reperfusion induces the release of diverse products from monocytes, including cytokines such as interleukin-1 (IL-1). To determine whether these phenomena modulate fibrinolysis and potentially exacerbate impairment of the macrocirculation, microcirculation, or both, we characterized the effects of IL-1 on the expression of fibrinolytic system and matrix proteins in rat cardiac microvascular endothelial cells (CMECs).
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