Block of the Rapid Component of the Delayed Rectifier Potassium Current by the Prokinetic Agent Cisapride Underlies Drug-Related Lengthening of the QT Interval | Zendy

Benoît Drolet | Zendy; Majed Khalifa | Zendy; Pascal Daleau | Zendy; Bettina A. Hamelin | Zendy; Jacques Turgeon | Zendy

Open Access

Block of the Rapid Component of the Delayed Rectifier Potassium Current by the Prokinetic Agent Cisapride Underlies Drug-Related Lengthening of the QT Interval

Author(s) -

Benoît Drolet,

Majed Khalifa,

Pascal Daleau,

Bettina A. Hamelin,

Jacques Turgeon

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.2.204

Subject(s) - cisapride , medicine , qt interval , prokinetic agent , drug , pharmacology , anesthesia , long qt syndrome , potassium , chemistry , organic chemistry

Lengthening of the QT interval and torsades de pointes resulting in cardiac arrests and deaths have been noticed during treatment with cisapride, a newly developed gastrointestinal prokinetic agent. The rapid (I[Kr]) and slow (I[Ks]) components of the delayed rectifier current (I[K]) are candidate ionic currents to explain cisapride-related toxicity because of their role in repolarization of cardiac ventricular myocytes. Our objectives were to (1) characterize effects of cisapride on two major time-dependent outward potassium currents involved in the repolarization of cardiac ventricular myocytes, I(Kr) and I(Ks), and (2) determine action potential-prolonging effects of cisapride on isolated hearts.

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