Pacing-Induced Heart Failure in Dogs Enhances the Expression of p53 and p53-Dependent Genes in Ventricular Myocytes | Zendy

Annarosa Leri | Zendy; Yu Liu | Zendy; Ashwani Malhotra | Zendy; Qiong Li | Zendy; Peter Stiegler | Zendy; Pier Paolo Claudio | Zendy; Antonio Giordano | Zendy; Jan Kajstura | Zendy; Thomas H. Hintze | Zendy; Piero Anversa | Zendy

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Pacing-Induced Heart Failure in Dogs Enhances the Expression of p53 and p53-Dependent Genes in Ventricular Myocytes

Author(s) -

Annarosa Leri,

Yu Liu,

Ashwani Malhotra,

Qiong Li,

Peter Stiegler,

Pier Paolo Claudio,

Antonio Giordano,

Jan Kajstura,

Thomas H. Hintze,

Piero Anversa

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.2.194

Subject(s) - dna laddering , myocyte , apoptosis , terminal deoxynucleotidyl transferase , microbiology and biotechnology , agarose gel electrophoresis , programmed cell death , dna damage , confocal microscopy , biology , medicine , tunel assay , dna , biochemistry , dna fragmentation

Rapid ventricular pacing in dogs is characterized by a dilated myopathy in which myocyte cell death by apoptosis may play a significant role in the impairment of cardiac pump function. However, the molecular mechanisms implicated in the modulation of programmed cell death under this setting remain to be identified. Moreover, questions have been raised on the specificity and sensitivity of the histochemical detection of DNA strand breaks in nuclei by the terminal deoxynucleotidyl transferase (TdT) reaction.

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