Increased Sensitivity to Nitric Oxide Synthase Inhibition in Patients With Heart Failure | Zendy

Joshua M. Hare | Zendy; Michael M. Givertz | Zendy; Mark A. Creager | Zendy; Wilson S. Colucci | Zendy

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Increased Sensitivity to Nitric Oxide Synthase Inhibition in Patients With Heart Failure

Author(s) -

Joshua M. Hare,

Michael M. Givertz,

Mark A. Creager,

Wilson S. Colucci

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.2.161

Subject(s) - dobutamine , medicine , heart failure , inotrope , cardiology , contractility , nitric oxide synthase , cardiac function curve , stimulation , endocrinology , nitric oxide , hemodynamics

We previously showed that cardiac nitric oxide (NO) inhibits the positive inotropic response to beta-adrenergic stimulation in humans with left ventricular (LV) dysfunction. Whether this effect is specific to heart failure per se or is a generalized feature of normal human myocardium is unknown. We therefore tested the hypothesis that inhibition of cardiac NO potentiates the positive inotropic response to beta-adrenergic stimulation in patients with symptomatic LV failure but not in subjects with normal LV function.

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