Polymorphism of the NADH/NADPH Oxidase p22 phox Gene in Patients With Coronary Artery Disease | Zendy

Nobutaka Inoue | Zendy; Seinosuke Kawashima | Zendy; Kenji Kanazawa | Zendy; Shinichiro Yamada | Zendy; Hozuka Akita | Zendy; Mitsuhiro Yokoyama | Zendy

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Polymorphism of the NADH/NADPH Oxidase p22 phox Gene in Patients With Coronary Artery Disease

Author(s) -

Nobutaka Inoue,

Seinosuke Kawashima,

Kenji Kanazawa,

Shinichiro Yamada,

Hozuka Akita,

Mitsuhiro Yokoyama

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.2.135

Subject(s) - nadph oxidase , genotype , restriction fragment length polymorphism , coronary artery disease , pathogenesis , medicine , gene polymorphism , endocrinology , oxidative stress , genetics , microbiology and biotechnology , biology , gene

Oxidative stress in the vasculature has been implicated in the pathogenesis of coronary artery disease (CAD). NADH/NADPH oxidase is a key enzyme of superoxide production in the vasculature. p22 phox, an essential component of NADH/NADPH oxidase, has four types of polymorphism. The C242T polymorphism changes histidine-72 to tyrosine, located in the potential heme-binding sites, whereas A640G polymorphism is located in the 3' untranslated region.

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