Constitutive Expression of phVEGF 165 After Intramuscular Gene Transfer Promotes Collateral Vessel Development in Patients With Critical Limb Ischemia | Zendy

Iris Baumgärtner | Zendy; Ann Pieczek | Zendy; Orit Manor | Zendy; Richard Blair | Zendy; Marianne Kearney | Zendy; Kenneth Walsh | Zendy; Jeffrey M. Isner | Zendy

Open Access

Constitutive Expression of phVEGF ₁₆₅ After Intramuscular Gene Transfer Promotes Collateral Vessel Development in Patients With Critical Limb Ischemia

Author(s) -

Iris Baumgärtner,

Ann Pieczek,

Orit Manor,

Richard Blair,

Marianne Kearney,

Kenneth Walsh,

Jeffrey M. Isner

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.12.1114

Subject(s) - medicine , critical limb ischemia , genetic enhancement , therapeutic angiogenesis , ischemia , angiogenesis , edema , vascular endothelial growth factor , pathology , ligation , surgery , vascular disease , neovascularization , gene , arterial disease , biochemistry , chemistry , vegf receptors

Preclinical studies have indicated that angiogenic growth factors can stimulate the development of collateral arteries, a concept called "therapeutic angiogenesis." The objectives of this phase 1 clinical trial were (1) to document the safety and feasibility of intramuscular gene transfer by use of naked plasmid DNA encoding an endothelial cell mitogen and (2) to analyze potential therapeutic benefits in patients with critical limb ischemia.

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