Vascular Endothelial Growth Factor/Vascular Permeability Factor Enhances Vascular Permeability Via Nitric Oxide and Prostacyclin | Zendy

Toyoaki Murohara | Zendy; Jeffrey R. Horowitz | Zendy; Marcy Silver | Zendy; Yukio Tsurumi | Zendy; Dongfen Chen | Zendy; Alison Sullivan | Zendy; Jeffrey M. Isner | Zendy

Open Access

Vascular Endothelial Growth Factor/Vascular Permeability Factor Enhances Vascular Permeability Via Nitric Oxide and Prostacyclin

Author(s) -

Toyoaki Murohara,

Jeffrey R. Horowitz,

Marcy Silver,

Yukio Tsurumi,

Dongfen Chen,

Alison Sullivan,

Jeffrey M. Isner

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.1.99

Subject(s) - vascular endothelial growth factor , vascular permeability , endocrinology , medicine , angiogenesis , prostacyclin , tyrosine kinase , basic fibroblast growth factor , prostaglandin , vascular endothelial growth factor a , growth factor , pharmacology , receptor , vegf receptors

Vascular endothelial growth factor (VEGF), an endothelial cell mitogen that promotes angiogenesis, was initially identified as a vascular permeability factor (VPF). Abundant evidence suggests that angiogenesis is preceded and/or accompanied by enhanced microvascular permeability. The mechanism by which VEGF/VPF increases vascular permeability (VP), however, has remained enigmatic. Accordingly, we used an in vivo assay of VP (Miles assay) to study the putative mediators of VEGF/VPF-induced permeability.

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