Increased Expression of Membrane-Type Matrix Metalloproteinase and Preferential Localization of Matrix Metalloproteinase-2 to the Neointima of Balloon-Injured Rat Carotid Arteries | Zendy

G. Mark Jenkins | Zendy; Michael T. Crow | Zendy; Claudio Bilato | Zendy; Yehezkiel A. Gluzband | Zendy; W. Ryu | Zendy; Zhihe Li | Zendy; William G. StetlerStevenson | Zendy; Cynthia Nater | Zendy; Jeffrey P. Froehlich | Zendy; Edward G. Lakatta | Zendy; Linda Cheng | Zendy

Open Access

Increased Expression of Membrane-Type Matrix Metalloproteinase and Preferential Localization of Matrix Metalloproteinase-2 to the Neointima of Balloon-Injured Rat Carotid Arteries

Author(s) -

G. Mark Jenkins,

Michael T. Crow,

Claudio Bilato,

Yehezkiel A. Gluzband,

W. Ryu,

Zhihe Li,

William G. StetlerStevenson,

Cynthia Nater,

Jeffrey P. Froehlich,

Edward G. Lakatta,

Linda Cheng

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.1.82

Subject(s) - neointima , matrix metalloproteinase , zymography , extracellular matrix , blot , medicine , vascular smooth muscle , tissue inhibitor of metalloproteinase , metalloproteinase , pathology , extracellular , anatomy , microbiology and biotechnology , biology , restenosis , biochemistry , smooth muscle , gene , stent

Remodeling of the injured vascular wall is dependent on the action of several extracellular proteases. Previous studies have shown that expression of matrix metalloproteinases (MMP-2 and MMP-9) is upregulated after vascular injury and that MMP-2 is required for the migration of cultured vascular smooth muscle cells across complex extracellular matrix barriers. The present study examined changes in the expression of membrane-type metalloproteinase (MT-MMP-1), a putative regulator of MMP-2, in the tissue localization of MMP-2, and in the expression of activated and latent forms of MMP-2 and the tissue inhibitor of metalloproteinases, TIMP-2, in rat carotid arteries subjected to balloon catheter injury.

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