Hyperpolarization-Activated Inward Current in Ventricular Myocytes From Normal and Failing Human Hearts | Zendy

Uta C. Hoppe | Zendy; Erik Jansen | Zendy; Michael Südkamp | Zendy; Dirk J. Beuckelmann | Zendy

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Hyperpolarization-Activated Inward Current in Ventricular Myocytes From Normal and Failing Human Hearts

Author(s) -

Uta C. Hoppe,

Erik Jansen,

Michael Südkamp,

Dirk J. Beuckelmann

Publication year - 1998

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.97.1.55

Subject(s) - medicine , myocyte , cardiology , endocrinology , hyperpolarization (physics) , stimulation , contraction (grammar) , heart failure , chemistry , organic chemistry , nuclear magnetic resonance spectroscopy

The hyperpolarization-activated inward current (I[f]) was found to be overexpressed in hypertrophied rat ventricular myocytes, indicating that I(f) might favor arrhythmias in hypertrophied or failing ventricular myocardium. In the present study, we evaluated whether I(f) is expressed in human ventricular myocardium, if it may be increased in human heart failure, and if its autonomic modulation may be altered.

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