Persistent thrombin generation in humans during specific thrombin inhibition with hirudin. | Zendy

Pierre Zoldhelyi | Zendy; J. Bichler | Zendy; Whyte G. Owen | Zendy; Diane E. Grill | Zendy; Valentı́n Fuster | Zendy; Jozef S. Mruk | Zendy; J. H. Chesebro | Zendy

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Persistent thrombin generation in humans during specific thrombin inhibition with hirudin.

Author(s) -

Pierre Zoldhelyi,

J. Bichler,

Whyte G. Owen,

Diane E. Grill,

Valentı́n Fuster,

Jozef S. Mruk,

J. H. Chesebro

Publication year - 1994

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.90.6.2671

Subject(s) - hirudin , thrombin , antithrombin , medicine , discovery and development of direct thrombin inhibitors , partial thromboplastin time , pharmacology , anesthesia , direct thrombin inhibitor , endocrinology , heparin , coagulation , platelet , dabigatran , warfarin , atrial fibrillation

The degree to which antithrombotic drugs suppress thrombin generation is unknown. Because hirudin, unlike antithrombin III, binds intravascular thrombin rapidly and selectively to yield a circulating inactive complex of 3- to 4-hour half-life, we used intravenous hirudin in humans to investigate the course of thrombin generation during and early after anticoagulation with this potent, direct antithrombin.

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