Cytomegalovirus infection-enhanced allograft arteriosclerosis is prevented by DHPG prophylaxis in the rat. | Zendy

Karl Lemström | Zendy; JOHAN HENDRIK BRUNING | Zendy; C. A. Bruggeman | Zendy; Petri Koskinen | Zendy; Päivi Aho | Zendy; S. Yilmaz | Zendy; I Lautenschlager | Zendy; P Häyry | Zendy

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Cytomegalovirus infection-enhanced allograft arteriosclerosis is prevented by DHPG prophylaxis in the rat.

Author(s) -

Karl Lemström,

JOHAN HENDRIK BRUNING,

C. A. Bruggeman,

Petri Koskinen,

Päivi Aho,

S. Yilmaz,

I Lautenschlager,

P Häyry

Publication year - 1994

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.90.4.1969

Subject(s) - medicine , betaherpesvirinae , arteriosclerosis , cytomegalovirus , transplantation , viremia , immunology , virus , surgery , herpesviridae , viral disease

Major risk factors for accelerated allograft arteriosclerosis include humoral and cellular immune response, hyperlipidemia, and viral infections. We demonstrated earlier that rat cytomegalovirus (RCMV) infection doubles smooth muscle cell proliferation and intimal thickening of rat aortic allografts. In this study, the effects of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) on RCMV-enhanced rat allograft arteriosclerosis are investigated.

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