Open AccessDecrease in myocardial ryanodine receptors and altered excitation-contraction coupling early in the development of heart failure.
Author(s) -
Dorothy E. Vatner,
Naoki Sato,
K Kiuchi,
Richard P. Shan,
Stephen F. Vatner
Publication year - 1994
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.90.3.1423
Subject(s) - ryanodine receptor , medicine , heart failure , contractility , endocrinology , contraction (grammar) , calcium , cardiology
Rapid ventricular pacing for 1 day reduced myocardial contractile function without inducing heart failure in conscious, chronically instrumented dogs. After 4 to 7 weeks of pacing, myocardial contractility was depressed further and overt signs of congestive heart failure, eg, ascites, dyspnea, and edema, were evident.
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