Open AccessLong-term oral administration of L-arginine reduces intimal thickening and enhances neoendothelium-dependent acetylcholine-induced relaxation after arterial injury.
Author(s) -
M. Hamon,
B. Vallet,
Christophe Bauters,
Nicolas Wernert,
E McFadden,
J M Lablanche,
B Dupuis,
M Bertrand
Publication year - 1994
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.90.3.1357
Subject(s) - medicine , arginine , nitric oxide , endothelium , acetylcholine , endocrinology , artery , hemodynamics , in vivo , balloon , anesthesia , chemistry , biochemistry , biology , amino acid , microbiology and biotechnology
Nitric oxide (NO), in addition to its potent vasorelaxant properties, may participate in growth regulation of cultured smooth muscle cells. It was recently demonstrated that in vivo endothelial injury induces the production of NO from L-arginine in the arterial wall.
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