Open AccessExistence and role of substrate cycling between AMP and adenosine in isolated rabbit cardiomyocytes under control conditions and in ATP depletion.
Author(s) -
Daniel R. Wagner,
Françoise Bontemps,
Greet Van den Berghe
Publication year - 1994
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.90.3.1343
Subject(s) - adenosine , adenosine deaminase inhibitor , adenosine kinase , nucleotidase , adenosine triphosphate , purinergic signalling , 5' nucleotidase , adenosine deaminase , medicine , biochemistry , endocrinology , chemistry , adenosine receptor , receptor , agonist
Adenosine, a physiological coronary vasodilator, has been proposed to regulate coronary circulation according to myocardial oxygen demand. In the present study, we investigated the mechanisms of adenosine formation and utilization in isolated rabbit cardiomyocytes and, in particular, the existence and the role of substrate cycling between AMP and adenosine in the regulation of its concentration.
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