Open AccessAdenovirus-mediated transfer of a gene encoding human apolipoprotein A-I into normal mice increases circulating high-density lipoprotein cholesterol.
Author(s) -
W P Kopfler,
Μ. D. Willard,
Timo Betz,
J. E. Willard,
Robert D. Gerard,
R S Meidell
Publication year - 1994
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.90.3.1319
Subject(s) - apolipoprotein b , cholesterol , medicine , endocrinology , lipoprotein , cholesterylester transfer protein , high density lipoprotein , recombinant dna , apolipoprotein e , genetic enhancement , gene , biology , biochemistry , disease
In animal models of atherosclerosis, augmentation of circulating high-density lipoprotein (HDL) cholesterol exerts a protective effect against development of fatty streaks and promotes plaque regression.
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