Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a porcine model of coronary artery balloon injury. | Zendy

Yi Shi | Zendy; Ali Fard | Zendy; A Galeo | Zendy; Howard G. Hutchinson | Zendy; P Vermani | Zendy; George R. Dodge | Zendy; David J. Hall | Zendy; Farida Shaheen | Zendy; Adam Zalewski | Zendy

Open Access

Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a porcine model of coronary artery balloon injury.

Author(s) -

Yi Shi,

Ali Fard,

A Galeo,

Howard G. Hutchinson,

P Vermani,

George R. Dodge,

David J. Hall,

Farida Shaheen,

Adam Zalewski

Publication year - 1994

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.90.2.944

Subject(s) - medicine , balloon , artery , cardiology

Smooth muscle cell proliferation and extracellular matrix accumulation are the principal mechanisms leading to vascular restenosis. We have previously demonstrated the growth-inhibitory effect of antisense oligomers targeting the c-myc proto-oncogene in human smooth muscle cells. The goal of this study was to investigate whether c-myc antisense oligomers reduce neointimal formation in balloon-denuded porcine coronary arteries.

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