Open AccessCharacterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies.
Author(s) -
Catherine M Otto,
Johanna Kuusisto,
Dennis D. Reichenbach,
A M Gown,
Kevin D. O’Brien
Publication year - 1994
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.90.2.844
Subject(s) - medicine , pathology , aortic valve , von kossa stain , lesion , elastin , stenosis , immunohistochemistry , anatomy , basement membrane , biology , biochemistry , alkaline phosphatase , enzyme
Nonrheumatic stenosis of trileaflet aortic valves, often termed senile or calcific valvular aortic stenosis, is considered a "degenerative" process, but little is known about the cellular or molecular factors that mediate its development.
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