Open AccessPrevention of arterial reocclusion after thrombolysis with activated protein C. Comparison with heparin in a canine model of coronary artery thrombosis.
Author(s) -
Tomohiro Sakamoto,
Hisao Ogawa,
Hirofumi Yasue,
Yutaka Oda,
Shuji Kitajima,
K. Tsumoto,
Hiroshi Mizokami
Publication year - 1994
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.90.1.427
Subject(s) - medicine , thrombolysis , heparin , cardiology , thrombosis , artery , anesthesia , myocardial infarction
Reocclusion of recanalized coronary arteries often limits the efficacy of coronary thrombolytic therapy in patients with acute myocardial infarction. Activated protein C (APC) is an important regulatory enzyme in hemostasis. In view of the potential of human APC as an anticoagulant and profibrinolytic agent, the effect of APC on thrombolysis with recombinant tissue-type plasminogen activator (rTPA) was studied in a canine model of coronary artery thrombosis.
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