Mechanism-specific effects of adenosine on atrial tachycardia. | Zendy

Erica D. Engelstein | Zendy; Neal Lippman | Zendy; Kenneth M. Steín | Zendy; Bruce B. Lerman | Zendy

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Mechanism-specific effects of adenosine on atrial tachycardia.

Author(s) -

Erica D. Engelstein,

Neal Lippman,

Kenneth M. Steín,

Bruce B. Lerman

Publication year - 1994

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.89.6.2645

Subject(s) - medicine , tachycardia , adenosine , cardiology , reentry , supraventricular tachycardia , atrial tachycardia , atrioventricular node , atrial flutter , electrophysiology , anesthesia , atrioventricular reentrant tachycardia , atrial fibrillation , accessory pathway , catheter ablation

Recent reports suggest that adenosine, in addition to terminating supraventricular tachycardia involving the atrioventricular (AV) node, may have antiarrhythmic effects on atrial tachycardia. The electrophysiological effects of adenosine on supraventricular tissue include shortening of action potential duration in atrial myocytes mediated by the potassium current, IKACh,Ado; shortening of action potential duration and hyperpolarization in sinus node cells; and anti-adrenergic electrophysiological effects resulting from inhibition of adenylyl cyclase. We therefore hypothesized that the response of atrial tachycardia to adenosine would be mechanism specific, with termination of atrial tachycardia due to sinus node reentry or cAMP-mediated triggered activity, transient suppression of automatic atrial tachycardia, and an absence of antiarrhythmic effect on tachycardia due to intraatrial reentry.

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