Open AccessPredicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with 201Tl and 99mTc-sestamibi.
Author(s) -
James E. Udelson,
Patrick S. Coleman,
Jeanne Metherall,
Natesa G. Pandian,
Asunción Gómez,
John L. Griffith,
Nancie L. Shea,
Elizabeth Oates,
Marvin A. Konstam
Publication year - 1994
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.89.6.2552
Subject(s) - medicine , cardiology , perfusion , revascularization , scintigraphy , coronary artery disease , single photon emission computed tomography , technetium tc 99m sestamibi , nuclear medicine , myocardial infarction
Regional 201Tl activity after resting injection, imaged early and after redistribution, reflects viable myocardium and can predict improved isotope uptake as well as regional and global ventricular function after revascularization. 99mTc-sestamibi, a perfusion tracer with favorable imaging characteristics, has distinct kinetics compared with 201Tl, demonstrating minimal redistribution; this property may give 201Tl an advantage for detecting viable myocardium, particularly in segments with resting hypoperfusion. The purpose of this study was to compare regional activities of 201Tl and 99mTc-sestamibi after resting injections in patients with coronary artery disease and regional or global left ventricular dysfunction and to assess their comparative abilities for predicting recovery of severe regional ventricular dysfunction after revascularization.
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