Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. | Zendy

Jonathan S. Stamler | Zendy; Evan Loh | Zendy; M A Roddy | Zendy; Kristen Currie | Zendy; Mark A. Creager | Zendy

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Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.

Author(s) -

Jonathan S. Stamler,

Evan Loh,

M A Roddy,

Kristen Currie,

Mark A. Creager

Publication year - 1994

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.89.5.2035

Subject(s) - vascular resistance , medicine , pulmonary artery , pulmonary wedge pressure , blood pressure , cardiology , nitric oxide , cardiac output , endothelium derived relaxing factor , hemodynamics , anesthesia

The endothelium synthesizes and releases a relaxing factor with the physiochemical properties of nitric oxide (NO). However, the role of endothelium-derived NO in the basal regulation of systemic and pulmonary vascular resistance in humans is not known. Our primary objectives were to determine the effects of inhibiting NO synthesis on blood pressure and systemic vascular resistance and to establish the role of endothelium-derived NO in the regulation of normoxic pulmonary vascular tone.

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