Open AccessEffect of L-arginine on coronary endothelial function in cardiac transplant recipients. Relation to vessel wall morphology.
Author(s) -
Helmut Drexler,
Tim A. Fischell,
Fausto J. Pinto,
Adrian Chenzbraun,
Javier Botas,
John P. Cooke,
Edwin L. Alderman
Publication year - 1994
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.89.4.1615
Subject(s) - medicine , cardiology , vasodilation , vasoconstriction , endothelial dysfunction , intravascular ultrasound , vascular resistance , endothelium , coronary circulation , coronary arteries , artery , coronary flow reserve , blood flow , hemodynamics
Coronary endothelial vasodilator dysfunction is a common finding in cardiac transplant recipients and may represent an early marker for the development of intimal thickening and graft atherosclerosis. The present study tested the hypothesis that endothelial dysfunction precedes intimal thickening and that administration of L-arginine, the precursor of endothelium-derived relaxing factor, improves endothelial vasodilator function of coronary conduit and resistance vessels if given at an early stage of graft atherosclerosis.
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