Open AccessVariable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women.
Author(s) -
Douglas W. Losordo,
Marianne Kearney,
E A Kim,
J Jekanowski,
Jeffrey M. Isner
Publication year - 1994
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.89.4.1501
Subject(s) - medicine , estrogen , coronary arteries , estrogen receptor , endocrinology , vascular smooth muscle , coronary artery disease , receptor , artery , coronary atherosclerosis , immunostaining , cardiology , immunohistochemistry , smooth muscle , cancer , breast cancer
The relative absence of coronary atherosclerosis in premenopausal women has been established. Estrogen is presumed to play a role in the protection of coronary arteries from atherosclerosis, and part of this protective effect appears to be mediated by amelioration of serum lipid profiles. However, all of the atheroprotective effect of estrogen is not explained by alteration of serum lipids. In this study, we attempt to identify evidence of estrogen receptors in coronary artery specimens of female patients and in human vascular smooth muscle cells.
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