Induction of myocardial insulin-like growth factor-I gene expression in left ventricular hypertrophy. | Zendy

Thomas J. Donohue | Zendy; L D Dworkin | Zendy; Miriam N. Lango | Zendy; K.H. Fliegner | Zendy; Romuald Lango | Zendy; Judith A. Benstein | Zendy; William Slater | Zendy; Veronica Catanese | Zendy

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Induction of myocardial insulin-like growth factor-I gene expression in left ventricular hypertrophy.

Author(s) -

Thomas J. Donohue,

L D Dworkin,

Miriam N. Lango,

K.H. Fliegner,

Romuald Lango,

Judith A. Benstein,

William Slater,

Veronica Catanese

Publication year - 1994

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.89.2.799

Subject(s) - medicine , endocrinology , left ventricular hypertrophy , muscle hypertrophy , ventricular hypertrophy , insulin like growth factor , afterload , blood pressure , pressure overload , growth factor , cardiology , receptor , cardiac hypertrophy

Left ventricular hypertrophy is a generalized adaptation to increased afterload, but the growth factors mediating this response have not been identified. To explore whether the hypertrophic response was associated with changes in local insulin-like growth factor-I (IGF-I) gene regulation, we examined the induction of the cardiac IGF-I gene in three models of systolic hypertension and resultant hypertrophy.

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