Ischemia induces translocation of the insulin-responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes. | Zendy

Duxin Sun | Zendy; Tat Nghia Nguyen | Zendy; Timothy R. DeGrado | Zendy; Markus Schwaiger | Zendy; Frank C. Brosius | Zendy

Open Access

Ischemia induces translocation of the insulin-responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes.

Author(s) -

Duxin Sun,

Tat Nghia Nguyen,

Timothy R. DeGrado,

Markus Schwaiger,

Frank C. Brosius

Publication year - 1994

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.89.2.793

Subject(s) - glut4 , glucose transporter , ischemia , medicine , insulin , chromosomal translocation , glucose uptake , endocrinology , myocyte , intracellular , biology , biochemistry , gene

Acute myocardial ischemia is accompanied by an increase in glucose uptake and metabolism, which appears to be important in protecting myocardial cells from irreversible ischemic injury. Because insulin augments myocardial glucose uptake by inducing the translocation of glucose transporters from an intracellular compartment to the plasma membrane, we hypothesized that acute ischemia would trigger a similar translocation.

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