Low-dose aspirin inhibits platelet-induced contraction of the human isolated coronary artery. A role for additional 5-hydroxytryptamine receptor antagonism against coronary vasospasm? | Zendy

Willem A. Bax | Zendy; G.J. Renzenbrink | Zendy; E A van der Linden | Zendy; Felix Zijlstra | Zendy; D. van Heuven-Nolsen | Zendy; Durk Fekkes | Zendy; Egbert Bos | Zendy; P.R. Saxena | Zendy

Open Access

Low-dose aspirin inhibits platelet-induced contraction of the human isolated coronary artery. A role for additional 5-hydroxytryptamine receptor antagonism against coronary vasospasm?

Author(s) -

Willem A. Bax,

G.J. Renzenbrink,

E A van der Linden,

Felix Zijlstra,

D. van Heuven-Nolsen,

Durk Fekkes,

Egbert Bos,

P.R. Saxena

Publication year - 1994

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.89.2.623

Subject(s) - medicine , platelet , aspirin , contraction (grammar) , ketanserin , thromboxane a2 , thromboxane , antagonist , receptor antagonist , artery , vasospasm , endocrinology , platelet activation , platelet aggregation inhibitor , pharmacology , receptor , serotonin , 5 ht receptor , subarachnoid hemorrhage

The beneficial effect of low-dose aspirin in the prevention of coronary vasospasm is well documented. In this study, we investigated the contractile effect of human washed platelets on the human isolated coronary artery. We concentrated on the effect of low-dose aspirin (40 mg/d) taken by the platelet donor and on the efficacy of thromboxane A2 (TXA2) and 5-hydroxytryptamine (5-HT) receptor antagonists.

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