Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women. | Zendy

Steven E. Reís | Zendy; Sean T. Gloth | Zendy; Roger S. Blumenthal | Zendy; Jon R. Resar | Zendy; Howard A. Zacur | Zendy; Gary Gerstenblith | Zendy; J A Brinker | Zendy

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Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women.

Author(s) -

Steven E. Reís,

Sean T. Gloth,

Roger S. Blumenthal,

Jon R. Resar,

Howard A. Zacur,

Gary Gerstenblith,

J A Brinker

Publication year - 1994

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.89.1.52

Subject(s) - medicine , vasomotor , acetylcholine , estrogen , endocrinology , placebo , basal (medicine) , vasodilation , coronary vasodilator , cardiology , pathology , alternative medicine , insulin

Estrogen administration in postmenopausal women is associated with a 50% reduction in the clinical manifestations of coronary artery disease. The mechanisms are not known, although one potential explanation is estrogen-induced modulation of coronary vasoreactivity. Acetylcholine is an endothelium-dependent vasodilator that may be used to assess coronary vasoreactivity and elicits coronary responses that parallel those found with common daily vasomotor stimuli. Therefore, we tested whether estrogen attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women.

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