Constrictor and dilator responses to intracoronary acetylcholine in adjacent segments of the same coronary artery in patients with coronary artery disease. Endothelial function revisited. | Zendy

Hassan ElTamimi | Zendy; M. Mansour | Zendy; Thomas J. Wargovich | Zendy; James A. Hill | Zendy; Richard A. Kerensky | Zendy; C Conti | Zendy; Carl J. Pepine | Zendy

Open Access

Constrictor and dilator responses to intracoronary acetylcholine in adjacent segments of the same coronary artery in patients with coronary artery disease. Endothelial function revisited.

Author(s) -

Hassan ElTamimi,

M. Mansour,

Thomas J. Wargovich,

James A. Hill,

Richard A. Kerensky,

C Conti,

Carl J. Pepine

Publication year - 1994

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.89.1.45

Subject(s) - medicine , dilator , cardiology , constriction , artery , acetylcholine , circumflex , coronary arteries , coronary artery disease , dilation (metric space) , coronary atherosclerosis , angina , myocardial infarction , mathematics , combinatorics

In patients with angiographically detectable atherosclerosis or in those with risk factors for coronary artery disease, intracoronary acetylcholine causes coronary constriction instead of endothelium-derived relaxing factor-mediated dilation. Therefore, it has been hypothesized that diffuse endothelial dysfunction precedes development of coronary atherosclerosis. We tested this hypothesis in a systematic investigation of the effects of ascending doses of acetylcholine on the diameters of nonstenotic segments of the left coronary artery in patients with advanced atherosclerosis and coronary risk factors.

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