Isoform-specific regulation of myocardial Na,K-ATPase alpha-subunit in congestive heart failure. Role of norepinephrine. | Zendy

C H Kim | Zendy; Tai-Hwang Fan | Zendy; Patrick Kelly | Zendy; Yoshihiro Himura | Zendy; Joseph M. Delehanty | Zendy; ChiLing Hang | Zendy; Changseng Liang | Zendy

Open Access

Isoform-specific regulation of myocardial Na,K-ATPase alpha-subunit in congestive heart failure. Role of norepinephrine.

Author(s) -

C H Kim,

Tai-Hwang Fan,

Patrick Kelly,

Yoshihiro Himura,

Joseph M. Delehanty,

ChiLing Hang,

Changseng Liang

Publication year - 1994

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.89.1.313

Subject(s) - ouabain , heart failure , medicine , norepinephrine , endocrinology , gene isoform , alpha (finance) , western blot , g alpha subunit , protein subunit , biology , chemistry , sodium , biochemistry , surgery , dopamine , construct validity , organic chemistry , patient satisfaction , gene

Myocardial ouabain-binding sites and Na,K-ATPase activity are reduced in congestive heart failure (CHF), but the mechanisms by which CHF reduces the Na,K-ATPase remain unknown. We proposed to investigate whether the changes are accompanied by isoform-specific reductions of the Na,K-ATPase alpha-subunit proteins in CHF and whether similar changes could be produced by exogenous norepinephrine administration.

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