Liposome-mediated gene transfer into human vascular smooth muscle cells. | Zendy

J. Geoffrey Pickering | Zendy; J Jekanowski | Zendy; L Weir | Zendy; S Takeshita | Zendy; Douglas W. Losordo | Zendy; J M Isner | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Liposome-mediated gene transfer into human vascular smooth muscle cells.

Author(s) -

J. Geoffrey Pickering,

J Jekanowski,

L Weir,

S Takeshita,

Douglas W. Losordo,

J M Isner

Publication year - 1994

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.89.1.13

Subject(s) - vascular smooth muscle , transfection , population , 3t3 cells , reporter gene , microbiology and biotechnology , genetic enhancement , biology , cell , cell culture , mitotic index , cationic liposome , medicine , gene expression , gene , mitosis , endocrinology , smooth muscle , biochemistry , genetics , environmental health

Complexing recombinant DNA with cationic liposomes is a convenient means of introducing foreign genes into cells (lipofection) and could potentially form the basis for genetically modifying diseased blood vessels in patients. The mechanism of lipofection is incompletely understood, but it is recognized that the degree of successful gene transfer is highly dependent on cell type. To date, there has been no reported experience with lipofection of human vascular smooth muscle cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research