Open AccessCirculating beta-atrial natriuretic factor in congestive heart failure in humans.
Author(s) -
C M Wei,
Pei-Chun Kao,
Junhong Lin,
Denise M. Heublein,
Hartzell V. Schaff,
John C. Burnett
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.88.3.1016
Subject(s) - medicine , heart failure , radioimmunoassay , endocrinology , beta (programming language) , brain natriuretic peptide , natriuretic peptide , cardiology , computer science , programming language
beta-Atrial natriuretic factor (beta-ANF) is an antiparallel dimer of alpha-ANF (alpha-ANF) with diminished cyclic GMP generation in vitro. To date, the presence of beta-ANF in the circulation of humans with severe congestive heart failure (CHF) remains controversial. The current study was designed to determine the presence and magnitude of circulating beta-ANF in severe CHF, to correlate plasma beta-ANF with the degree of ventricular dysfunction, and to investigate the role of human plasma and atrial tissue in the degradation of beta-ANF.
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