Early and late effects of leukopenic reperfusion on the recovery of cardiac contractile function. Studies in the transplanted and isolated blood-perfused rat heart. | Zendy

Manuel Galiñanes | Zendy; Clive S. Lawson | Zendy; Roberto Ferrari | Zendy; G. Astrid Limb | Zendy; N W Derias | Zendy; David J. Hearse | Zendy

Open Access

Early and late effects of leukopenic reperfusion on the recovery of cardiac contractile function. Studies in the transplanted and isolated blood-perfused rat heart.

Author(s) -

Manuel Galiñanes,

Clive S. Lawson,

Roberto Ferrari,

G. Astrid Limb,

N W Derias,

David J. Hearse

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.88.2.673

Subject(s) - medicine , ischemia , saline , perfusion , anesthesia , fissipedia , cardiology

Since there is considerable evidence that leukocytes contribute to tissue injury during ischemia and reperfusion, the present study was designed to: (1) determine whether reperfusion in vivo with leukopenic blood affords protection in a model of reversible hypothermic ischemia, (2) determine the duration of any protection, (3) characterize the relation between protection and duration of leukopenic perfusion, and (4) assess the effect of leukopenic reperfusion on myocardial glutathione content.

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