Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium. | Zendy

Andrew S. Weyrich | Zendy; David J. Lefer | Zendy; Michael Buerke | Zendy; Kurt H. Albertine | Zendy; T K Kishimoto | Zendy; A M Lefer | Zendy

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Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium.

Author(s) -

Andrew S. Weyrich,

David J. Lefer,

Michael Buerke,

Kurt H. Albertine,

T K Kishimoto,

A M Lefer

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.88.2.649

Subject(s) - medicine , ischemia , myeloperoxidase , monoclonal antibody , endothelial dysfunction , cd18 , granulocyte , p selectin , reperfusion injury , endothelium , selectin , pharmacology , immunology , inflammation , antibody , platelet , platelet activation

Interaction of CD11/CD18 located on neutrophil membranes with its endothelial counter-receptor, intercellular adhesion molecule-1, plays a major role in polymorphonuclear leukocyte (PMN)-mediated endothelial dysfunction and myocardial injury associated with ischemia and reperfusion. However, PMN-derived L-selectin, which is thought to play an early role in PMN rolling along the vascular endothelium, has not been studied in a setting of myocardial ischemia and reperfusion.

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