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Bamiphylline improves exercise-induced myocardial ischemia through a novel mechanism of action.
Author(s) -
Achille Gaspardone,
Filippo Crea,
Maria Iamele,
Fabrizio Tomai,
Francesco Versaci,
Antonio Pellegrino,
Luigi Chiariello,
Pier Agostino Gioffrè
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.88.2.502
Subject(s) - medicine , aminophylline , cardiology , heart rate , ejection fraction , angina , placebo , rate pressure product , anesthesia , blood pressure , supine position , adenosine , ischemia , myocardial infarction , heart failure , alternative medicine , pathology
In patients with stable angina pectoris aminophylline, a nonselective antagonist of adenosine receptors, markedly improves exercise capacity. To establish the role played by A1 adenosine receptors in the anti-ischemic action of aminophylline, the effects of bamiphylline, a selective A1 antagonist, on exercise-induced ischemia were investigated in patients with stable angina pectoris.

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