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Lisinopril lowers cardiac adrenergic drive and increases beta-receptor density in the failing human heart.
Author(s) -
Edward M. Gilbert,
Anthony Sandoval,
Patricia S. Larrabee,
Dale G. Renlund,
John B. OʼConnell,
Michael R. Bristow
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.88.2.472
Subject(s) - medicine , lisinopril , norepinephrine , heart failure , endocrinology , coronary sinus , angiotensin converting enzyme , adrenergic , adrenergic receptor , cardiology , angiotensin ii , ace inhibitor , receptor , blood pressure , dopamine
In subjects with heart failure, angiotensin converting enzyme inhibitors exhibit mild systemic antiadrenergic effects, as deduced from treatment-related lowering of systemic venous norepinephrine levels. The effects of angiotensin converting enzyme inhibitors on cardiac adrenergic drive in subjects with heart failure has not previously been investigated.

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