Suppression of insulin-induced sympathetic activation and vasodilation by dexamethasone in humans. | Zendy

Urs Scherrer | Zendy; Péter Vollenweider | Zendy; D Randin | Zendy; E Jéquier | Zendy; Pascal Nicod | Zendy; Luc Tappy | Zendy

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Suppression of insulin-induced sympathetic activation and vasodilation by dexamethasone in humans.

Author(s) -

Urs Scherrer,

Péter Vollenweider,

D Randin,

E Jéquier,

Pascal Nicod,

Luc Tappy

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.88.2.388

Subject(s) - hyperinsulinemia , medicine , endocrinology , insulin , vasodilation , sympathetic nervous system , dexamethasone , hemodynamics , skeletal muscle , blood pressure , insulin resistance

Physiological hyperinsulinemia in lean human subjects stimulates sympathetic nerve activity and blood flow in skeletal muscle, but the underlying mechanism is unknown. Potential mechanisms include central neural or peripheral actions of insulin. Glucocorticoids may potentially interfere with both such actions and thereby may attenuate sympathoexcitatory and vasodilatory effects of insulin in skeletal muscle.

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