Molecular forms of atrial natriuretic factor in normal and failing human myocardium. | Zendy

Richard J. Rodeheffer | Zendy; M Naruse | Zendy; James B. Atkinson | Zendy; Kiyoko Naruse | Zendy; J. C. Burnett | Zendy; Walter H. Merrill | Zendy; William H. Frist | Zendy; Hiroshi Demura | Zendy; Tadashi Inagami | Zendy

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Molecular forms of atrial natriuretic factor in normal and failing human myocardium.

Author(s) -

Richard J. Rodeheffer,

M Naruse,

James B. Atkinson,

Kiyoko Naruse,

J. C. Burnett,

Walter H. Merrill,

William H. Frist,

Hiroshi Demura,

Tadashi Inagami

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.88.2.364

Subject(s) - medicine , atrial appendage , heart failure , heart transplantation , appendage , transplantation , endocrinology , cardiology , atrial natriuretic peptide , anatomy , atrial fibrillation , sinus rhythm

Atrial natriuretic factor (ANF) is produced by myocardial tissue, and the plasma ANF concentration is known to be elevated in congestive heart failure (CHF). Data from animal models indicate that myocardial concentrations of ANF are depleted in CHF, and this has given rise to the hypothesis that CHF is characterized by depletion of stored ANF. To date, the molecular forms of ANF and their concentrations in atrial and ventricular myocardium remain poorly characterized in the normal and the failing human heart.

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