Open AccessReflex sympathoexcitation by cardiac sympathetic afferents during myocardial ischemia. Role of adenosine.
Author(s) -
M D Thames,
Toru Kinugawa,
Mark E. DibnerDunlap
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.87.5.1698
Subject(s) - medicine , adenosine , cardiology , reflex , anesthesia , ischemia , adenosine receptor , aminophylline , receptor , agonist
Stimulation of cardiac sympathetic afferents during myocardial ischemia has been attributed to bradykinin released from the ischemic myocardium. Recent data from human studies suggest that adenosine may serve as this mediator. Our experiments were done to determine whether reflex sympathoexcitatory responses to activation of cardiac sympathetic afferents during myocardial ischemia could be inhibited by blockade of adenosine receptors and augmented by increasing the local concentrations of adenosine in the ischemic myocardium.
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