Cyclosporine A has no direct effect on collagen metabolism by cardiac fibroblasts in vitro. | Zendy

Elias G. Eleftheriades | Zendy; A. G. Ferguson | Zendy; Allen M. Samarel | Zendy

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Cyclosporine A has no direct effect on collagen metabolism by cardiac fibroblasts in vitro.

Author(s) -

Elias G. Eleftheriades,

A. G. Ferguson,

Allen M. Samarel

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.87.4.1368

Subject(s) - procollagen peptidase , collagenase , medicine , fibrosis , hydroxyproline , endocrinology , cardiac fibrosis , northern blot , myocyte , in vitro , cardiac function curve , interstitial collagenase , gene expression , heart failure , biology , biochemistry , enzyme , gene

Cyclosporine A has been implicated in the pathogenesis of myocardial interstitial fibrosis observed in heart transplant recipients. However, other confounding variables such as posttransplantation hypertension and rejection episodes may also be responsible for interstitial fibrosis development and associated abnormalities in ventricular diastolic function. Therefore, we examined whether cyclosporine A directly or indirectly affects fibrillar collagen metabolism by cardiac fibroblasts in vitro.

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