Superoxide dismutase restores contractile and metabolic dysfunction through augmentation of adenosine release in coronary microembolization.
Author(s) -
Seiji Takashima,
M Hori,
Masafumi Kitakaze,
Hideyuki Sato,
Michitoshi Inoue,
Tomoari Kamada
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.87.3.982
Subject(s) - medicine , adenosine , superoxide dismutase , coronary circulation , ischemia , blood flow , artery , hemodynamics , cardiology , anesthesia , endocrinology , oxidative stress
This study was undertaken to test the hypothesis that administration of superoxide dismutase (SOD) restores the contractile and metabolic dysfunction in coronary microembolization and that these beneficial effects of SOD are attributable to the restoration of 5'-nucleotidase activity and subsequent augmentation of adenosine release.
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