Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation. | Zendy

Tom L. Broderick | Zendy; H. Arthur Quinney | Zendy; Collin C. Barker | Zendy; Gary D. Lopaschuk | Zendy

Open Access

Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation.

Author(s) -

Tom L. Broderick,

H. Arthur Quinney,

Collin C. Barker,

Gary D. Lopaschuk

Publication year - 1993

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/01.cir.87.3.972

Subject(s) - carnitine , medicine , endocrinology , perfusion , glycolysis , ischemia , beta oxidation , anaerobic glycolysis , stimulation , glucose uptake , carbohydrate metabolism , metabolism , insulin

We have previously shown that increasing myocardial carnitine levels in fatty acid-perfused isolated working rat hearts dramatically increases glucose oxidation rates. Since high levels of fatty acids depress reperfusion recovery of ischemic hearts by inhibiting glucose oxidation, we determined what effect carnitine has on glucose oxidation during reperfusion of ischemic hearts.

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