Open AccessHeat-shock response and limitation of tissue necrosis during occlusion/reperfusion in rabbit hearts.
Author(s) -
R. William Currie,
R M Tanguay,
John G. Kingma
Publication year - 1993
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/01.cir.87.3.963
Subject(s) - medicine , rabbit (cipher) , necrosis , shock (circulatory) , cardiology , coronary occlusion , occlusion , lagomorpha , statistics , mathematics
Induction of stress proteins, such as heat-shock protein 71 (HSP71), is associated with cardioprotection in isolated ischemic myocardium. We tested this hypothesis in rabbits pretreated with whole-body hyperthermia and then subjected to 30 or 45 minutes of regional coronary occlusion (CO) followed by 3 hours reperfusion (Rep).
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